
Prepare
Degrease, standardise pH and prime the epidermis.
5-agent multi-mechanism chemical peel designed for treatment-resistant melasma that has failed standard depigmentation protocols. Formulated with PMK-5S Complex.

Pyruvic Acid · Mandelic Acid · Beta Hydroxy Acid · Kojic Acid · TCA
Penta-Agent Stubborn Melasma™
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Not sure it fits your patient? Ask us ↗Pyruvic Acid provides deep penetration, Mandelic Acid ensures uniform surface exfoliation, BHA reduces inflammation, Kojic Acid blocks pigment production, and TCA delivers controlled medium-depth peeling at the skin's deeper layers.
Five distinct mechanisms attacking stubborn pigment from five penetration depths simultaneously. ~7 sessions per 30ml jar.
Penta-Agent Stubborn Melasma™
5-agent multi-mechanism system specifically designed for stubborn melasma that has failed standard protocols

Five different mechanisms attack stubborn melasma from five angles — pyruvic goes deep, mandelic ensures uniformity, BHA reduces inflammation, kojic blocks pigment, TCA provides controlled deeper peel where needed




Pyruvic (penetration), Mandelic (surface), TCA (coagulation), Kojic (brightening). Multi-vector attack on stubborn pigment.
Pyruvic Acid, Mandelic Acid, BHA, Kojic Acid, TCA, Liquorice Extract, Tea Tree Extract, Allantoin
Indications and suitability.

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Degrease, standardise pH and prime the epidermis.

Apply according to this product’s protocol and jar label.

Use the product-specific endpoint instructions below; neutralisation depends on the selected formulation.

Follow post-procedure care instructions.
Essentials are one unit each. Clinic pricing and availability are confirmed on WhatsApp before you order.
3–4 sessions · 21–28 day intervals · 30 sec–3 min maximum · TCA frost endpoint monitoring required
Cleanse and prep skin thoroughly
Apply product as directed by protocol
Follow post-procedure care instructions
The practical details, before you order.
Estimated pH 1.2–1.9, with medium confidence, inferred from acid pKa and buffering. This is not a batch measurement and must not be used as a batch specification.
101 reviews of prodermic 600 · 101 from verified orders
101 reviews
Epidermal melanin index dropped visibly on mexameter evaluation after the second pass of 600. Subtle micro-flaking with 600 rather than sheets; patient needed reassurance that deeper renewal was occurring.
One of my Fitzpatrick IV patients had zero visible desquamation with 600, yet her treatment di-resistant melasma cleared visibly by week three. Works reliably across our chairs with 600. Would appreciate larger back-bar sizes for clinic use.
Moderate results on treatment di-resistant melasma. Fine for superficial dullness, but deeper textural scars needed alternative modality.
Recalcitrant treatment di-resistant melasma that failed topical combinations finally showed movement after the 3rd session. Our clinic's primary protocol for treatment di-resistant melasma now. Dependable outcomes across different skin tones.
First shipment of 600 was misplaced by courier and resent. The peel itself is acceptable, but booking was delayed. Reordered 600 twice for our branch clinic. Batch-to-batch consistency is dependable.
Mild micro-dusting only, great clearance with 600.
From formulation to follow-up.
Prodermic Clinical Course
Free, self-paced, written for practising dermatologists. The rationale behind every line on the label.
Start the module ↗Learn the technique
The clinical course module behind 600.
Most often ordered alongside 600.
435 ↗Medium-depth multi-agent depigmentation system designed for resistant melasma and deep PIH that superficial peels cannot address.
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555 ↗Amino acid-enhanced 5-agent depigmentation system designed for deep, stubborn pigmentation that has not responded to standard acid protocols.
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565 ↗Gentle quad-acid depigmentation system specifically formulated for sensitive, rosacea-prone, and reactive skin types that cannot tolerate aggressive peels.
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580 ↗Retinoic-acid combination peel for melasma, post-inflammatory hyperpigmentation and sun damage.
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