
Prepare
Degrease, standardise pH and prime the epidermis.
4-agent detoxification system built around Black Acetic Acid for deep impurity extraction, combined with a tri-acid purification complex for comprehensive congestion clearing and skin renewal. Formulated with BAC-4D Complex.

Black Acetic Acid · Salicylic Acid · Mandelic Acid · Lactic Acid
Carbon Detox Architecture™
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Not sure it fits your patient? Ask us ↗The BAC-4D Complex pairs Black Acetic Acid's activated carbon-like drawing properties with Salicylic Acid for deep pore decongestion, Mandelic Acid for uniform antibacterial penetration, and high-dose Lactic Acid for intense hydrating exfoliation with skin barrier support.
The go-to urban detox peel for pollution-exposed, congested, and dull skin. ~24 sessions per 30ml jar.
Carbon Detox Architecture™
Unique carbon-based detoxification peel with black acetic acid for deep purification and congestion clearing

Deep detoxification, draws impurities, antimicrobial.

Unclogs pores

Provides antibacterial coverage

Aggressive hydration + exfoliation, ceramide synthesis.
Salicylic + Mandelic for pore clearing.
Black Acetic Acid, Salicylic Acid, Mandelic Acid, Lactic Acid, Liquorice Extract, Tea Tree Extract
Indications and suitability.



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Degrease, standardise pH and prime the epidermis.

Apply according to this product’s protocol and jar label.

Use the product-specific endpoint instructions below; neutralisation depends on the selected formulation.

Follow post-procedure care instructions.
Essentials are one unit each. Clinic pricing and availability are confirmed on WhatsApp before you order.
4–6 sessions · 14-day intervals · 5–15 min clinician-controlled contact · neutralize fully at endpoint
Cleanse and prep skin thoroughly
Apply product as directed by protocol
Follow post-procedure care instructions
The practical details, before you order.
Estimated pH 1.8–2.6, with medium confidence, inferred from acid pKa and buffering. This is not a batch measurement and must not be used as a batch specification.
118 reviews of prodermic 421 · 118 from verified orders
118 reviews
Patients often expect sheets of skin shedding like social media videos; I counsel them that controlled micro-exfoliation with 421 delivers far safer melanin clearance without barrier damage. Running PREP.01 degreasing followed by 421 and NEUT.01 gives reproducible results every single session.
Thank you Prodermic 🙏
Visible softening of textural irregularities and detoxification cleared up noticeably by week 4 of using 421. Our clinic's primary protocol for detoxification now with 421. Dependable outcomes across different skin tones.
421 replaced the imported peel we were stocking for detoxification. Three doctors here use it and the result from each chair is the same. Switched the whole detoxification protocol to it for consistency across staff. Tracking was accurate and the invoice matched the PO. Good value for a professional product.
Patients often expect sheets of skin shedding like social media videos; I counsel them that controlled micro-exfoliation with 421 delivers far safer melanin clearance without barrier damage. Consistent clinical performance with 421. Patient compliance with daily broad-spectrum SPF was the main variable.
Warned the patient she might only get micro-dusting rather than sheets of peeling; she was thrilled that 421 cleared her detoxification without visible downtime. Clean endpoint reading with Black Peel Protocol makes training junior associate clinicians straightforward and safe.
From formulation to follow-up.
Prodermic Clinical Course
Free, self-paced, written for practising dermatologists. The rationale behind every line on the label.
Start the module ↗Learn the technique
The clinical course module behind 421.
Most often ordered alongside 421.
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