Glutathione Peel

590

Antioxidant-driven depigmentation system for visible brightening from session one

Depth
Superficial to Medium
Contact
8–25 min
Neutralize
Requires neutralization
Fitzpatrick
II–V
Sessions
4–6
Downtime
2–5 days

Overview

Antioxidant-driven depigmentation system for visible brightening from session one

01

Safety

Contraindications

  • Active dermatitis, eczema, or skin infection in treatment area
  • Pregnancy or breastfeeding
  • Isotretinoin use within the last 6 months
  • Topical retinoid use within 72 hours
  • Open wounds, abrasions, or broken skin
  • History of keloid or hypertrophic scarring
  • Known allergy to glutathione, kojic acid, or any component
  • Recent laser, IPL, or dermabrasion within 2 weeks
  • Active herpes simplex in treatment area
  • Sunburned or irritated skin

Neutralize Immediately If

  1. Severe burning or escalating pain
  2. Intense erythema (deep red or blanching)
  3. Visible edema or swelling
  4. Urticaria (hives) or welts
  5. White frosting or grey discoloration
  6. Patient distress or inability to tolerate

Stop the procedure and neutralize with cold water or sodium bicarbonate.

02

Composition

IngredientConcentrationRole
Glutathione (15%)Master antioxidant — converts eumelanin (dark pigment) to phaeomelanin (lighter form) via pheomelanin switching pathway
Glycolic Acid (25%)Alpha-hydroxy acid that disrupts corneocyte cohesion for controlled exfoliation and enhanced penetration of actives
Kojic Acid (15%)Chelates copper ions essential for tyrosinase activity, directly inhibiting melanin biosynthesis
Lactic Acid (10%)Gentle AHA providing hydration-coupled exfoliation, reduces post-inflammatory hyperpigmentation risk
Salicylic Acid (2%)Lipophilic BHA — penetrates sebaceous follicles, clears pore-level pigment deposits and prevents comedonal recurrence
03

Indications

Fitzpatrick II–V
  • Melasma
  • Post-Inflammatory Hyperpigmentation
  • Full-Body Brightening
  • Solar Lentigines
  • Dull & Sallow Complexion
  • Uneven Skin Tone
04

Procedure

  1. 01

    Cleanse & Degrease

    3–4 min

    Double-cleanse: first with micellar water to remove surface impurities, then with pre-peel degreasing solution applied with gauze in upward strokes.

    • Degreasing contact: 1–2 minutes. Wipe clean. Allow skin to fully air-dry for 30 seconds before application.
  2. 02

    Patch Test (First Session)

    10 min

    Apply a small amount behind the ear or on the inner forearm. Observe for 10 minutes for erythema, itching, or adverse reaction.

    • Mandatory for first-time patients. If irritation occurs, do not proceed. Document result in patient chart.
  3. 03

    Apply prodermic 590

    3–4 min

    Using a fan brush, apply 1–1.5ml of product in a thin, uniform layer. Work systematically: forehead → cheeks → nose → chin → upper lip. Avoid eyelids, lips, and nostrils.

    • Total active concentration is 67%. Start with minimal contact time and build gradually across sessions.
  4. 04

    Monitor & Titrate

    8–25 min

    Observe skin response continuously. Target endpoint: uniform mild erythema (pink flush). Slight tingling is expected. Watch for frosting, intense redness, or patient discomfort.

    • Session 1: 8–10 min max. Session 2: 12–15 min. Session 3+: up to 20–25 min based on tolerance.
  5. 05

    Neutralize

    2–3 min

    Apply neutralizing solution (sodium bicarbonate or prodermic neutralizer) generously. Gently remove all product residue with damp gauze. Rinse with cold water.

    • Neutralize thoroughly — residual glycolic or salicylic acid can cause post-peel burns. Confirm skin pH has returned to normal.
  6. 06

    Post-Peel Care & Discharge

    3–5 min

    Apply recovery balm or soothing moisturizer. Layer with SPF 50+ broad-spectrum sunscreen. Provide written post-care instructions and schedule follow-up.

    • No actives, makeup, or sun exposure for remainder of the day. Emphasize SPF compliance for pigmentation patients.
05

Post-procedure

Daily regimen
Day 0Peel Day Recovery moisturizer applied in clinic. No actives, makeup, or sun exposure for remainder of day. Sleep on clean pillowcase.
Days 1–2Tightness Phase Skin may feel tight and dry. Gentle cleanser 2x daily. Rich moisturizer 3–4x daily. SPF 50+ mandatory before any sun exposure.
Days 3–5Peeling Phase Mild flaking may occur. Do NOT pick or force peeling. Continue intensive moisturization and strict SPF.
Days 5–7Recovery Skin renewal visible. Resume light makeup if needed. Avoid retinoids, AHAs, and BHAs until Day 7.
Days 7–14Between Sessions Maintain SPF 50+. Resume normal skincare. Glutathione-based home care or Vitamin C serum can enhance results.
06

Session plan

Sessions
4–6
Interval
14–21 days
Downtime
2–5 days
Total
2–4 months
Progressive dose schedule
SessionContact time
Session 18–10 min
Session 212–15 min
Session 315–20 min
Session 4+20–25 min (max)

After completing the initial program, 1 maintenance session every 4–6 weeks sustains brightening results. Combine with prodermic VC.sr (Vitamin C Serum) or NVC.sr (Niacinamide Serum) for home care.