Overview
Step-by-step clinical application guide for practitioners
Safety
Contraindications
- Active skin infections in treatment area
- Compromised skin barrier
- Pregnancy or breastfeeding
- Isotretinoin use within the last 6 months
- Topical tretinoin use within 72 hours
- Open wounds or broken skin in treatment area
- Known allergy to any component
Wash Off Immediately If
- Severe burning or pain
- Excessive redness
- Hives or welts (urticaria)
- Blistering
Stop the procedure and neutralize with cold water or sodium bicarbonate.
Composition
| Ingredient | Concentration | Role |
|---|---|---|
| Arginine | Amino acid that enhances microcirculation and supports cellular repair | |
| Mandelic Acid | Lipophilic AHA providing gradual, even penetration for uniform exfoliation | |
| Kojic Acid | Chelates copper required for tyrosinase activity, blocking melanin synthesis | |
| Lactic Acid | Hydrating exfoliation, supports ceramide synthesis, gentle surface renewal | |
| Glycolic Acid | Surface exfoliation, disrupts corneocyte cohesion for controlled desquamation |
Indications
- Deep Pigmentation
- Fitzpatrick III–V Skin
- Stubborn Melasma
Procedure
- 01
Cleanse & Degrease
2–3 minCleanse with gentle non-residue cleanser. Remove makeup, sunscreen, surface impurities. Degrease skin using pre-peel degreasing solution with gauze.
- Degreasing contact: 1–2 minutes. Wipe clean. Allow skin to dry for 30 seconds.
- 02
Patch Test
10 minApply a small amount behind the ear or on the inner forearm. Observe for 10 minutes for any adverse reaction.
- First session only. If erythema, itching, or swelling occurs, do not proceed.
- 03
Apply prodermic 555
2–3 minApply 1–1.25ml of product using a fan brush or gauze. This formulation contains a unique arginine component. Apply in thin, even layers.
- Unique arginine component enhances microcirculation during treatment.
- 04
Observe Initial Response
5–10 minMonitor the skin for 5–10 minutes in-clinic. Ensure no adverse reaction. Mild warmth and slight pinkness are normal.
- If excessive redness, burning, or hives appear, wash off immediately.
- 05
Clinician-Controlled Contact
5–15 minMonitor continuously for 5–15 minutes. Final timing depends on Fitzpatrick type, barrier integrity, treatment history, and live skin response.
- The treating doctor’s endpoint decision is final; stop earlier for excessive erythema, burning, hives, or escalating discomfort.
- 06
Neutralize & Recover
2–3 minApply neutralizer according to protocol, remove all residue, rinse with cool water, and apply recovery moisturizer.
- No actives or makeup for the rest of the day. Apply SPF 50+ before sun exposure.
Post-procedure
| Day 0 | Peel Day Neutralize fully in clinic, rinse with cool water, and apply recovery moisturizer. No actives/makeup. |
| Days 1–2 | Tightness Phase Skin tight, dry, may darken in pigmented areas. Gentle cleanser 2x daily. Thick moisturizer 3–4x. SPF 50+. |
| Days 3–5 | Peeling Phase Visible flaking begins. Do NOT force peeling. Continue moisturizer + SPF 50+. |
| Days 5–7 | Recovery Peeling mostly complete. Resume light makeup. Avoid harsh actives until Day 7. |
| Days 7–14 | Between Sessions Strict sun protection. Resume normal skincare. Next session in 14 days. |
Session plan
| Session | Contact time |
|---|---|
| Session 1 | 5 min starting window |
| Session 2 | 5–10 min, response-led |
| Session 3 | Up to 10–15 min if clinically appropriate |
| Session 4+ | Maximum 15 min; endpoint overrides timer |
Expected results
Clinical outcomes from supervised sessions. Actual results depend on skin type, adherence to protocol, and sun protection.